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Proceedings Paper

Influence of temperature on the precision of noninvasive glucose sensing by near-infrared spectroscopy
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Paper Abstract

The use of near-infrared spectroscopy for the monitoring of blood glucose concentration is limited by many ambiguous factors, which leads to the prediction precision is not satisfied. Due to the weak interested signal and the difficulty to quantify the physiological noise directly, the absorbance induced by glucose concentration and temperature was analyzed based on Beer-Lambert Law and displacement between glucose and water. Then the transmittance of glucose aqueous solution in different temperatures was measured by spectrometer to investigate the influence of glucose concentration and temperature. As it's difficult to distinguish the influence of temperature from the diffuse reflectance, the Monte Carlo simulation was used to compute the light intensity induced by the change in glucose concentration and physiological temperature. Finally, the influence of actual physiological temperature on the prediction model of glucose concentration was estimated based on the oral glucose tolerance tests of two diabetics. The result showed that, near the normal physiological temperature, the intensity of diffuse reflectance caused by -0.1 °C change in temperature was equivalent to that caused by 2.7 mmol/L change in glucose concentration. Moreover, the proportion of prediction error induced by temperature to the total error was more than 50%.

Paper Details

Date Published: 22 February 2008
PDF: 10 pages
Proc. SPIE 6863, Optical Diagnostics and Sensing VIII, 68630Q (22 February 2008); doi: 10.1117/12.762152
Show Author Affiliations
Rong Liu, Tianjin Univ. (China)
Wenliang Chen, Tianjin Univ. (China)
Yun Chen, Tianjin Univ. (China)
Kexin Xu, Tianjin Univ. (China)

Published in SPIE Proceedings Vol. 6863:
Optical Diagnostics and Sensing VIII
Gerard L. Coté; Alexander V. Priezzhev, Editor(s)

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