
Proceedings Paper
The role of autofluorescence diagnostics in the diseases of oral mucosaFormat | Member Price | Non-Member Price |
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Paper Abstract
Introduction. Life induced fluorescence (LIFE) diagnostics can be used as an imaging system of
precancerous and neoplastic lesions of the oral mucosa. Neoplastic lesions are visible in pseudo colours,
healthy tissue in green colour and abnormal tissue in red colour. All the observed colours present
different intensity. Colour intensity is relevant to the grade of dysplasia, carcinoma progress and is called
Numerological Value of Color Index (NCV). The aim of our study was to find correlation between
autofluorescence diagnostics combined with NCV assessment and histopathological findings of taken
specimen biopsies. Patients and methods. 10 patients participated in our study. Lesions affected a variety of
intraoral sites. The most common location was: buccal, gingival and mandibular mucosa. Patients were
examined using Life Induced Fluorescence diagnosis (400 - 750 nm wavelength) with Numerological
Value of Color index (NCV) using Onco LIFE system. Afterwards the specimen biopsies from the lesions
were taken and histopathological examination was performed. Results. Different NCV and dependence of
NCV on the histopathological findings were observed. Conclusion. Diagnostic procedures with the
application of white-light imaging with LIFE imaging is not only a significantly faster method and a
better diagnostic tool of preneoplastic and neoplastic lesions, but there exist also correlations between
measured NCV and histopathological diagnosis. The farther investigations are necessary in order to prove
these preliminary findings.
Paper Details
Date Published: 11 February 2008
PDF: 8 pages
Proc. SPIE 6845, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XVII, 68450Y (11 February 2008); doi: 10.1117/12.762116
Published in SPIE Proceedings Vol. 6845:
Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XVII
David Kessel, Editor(s)
PDF: 8 pages
Proc. SPIE 6845, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XVII, 68450Y (11 February 2008); doi: 10.1117/12.762116
Show Author Affiliations
A. Kosciarz-Grzesiok, Medical Univ. of Silesia (Poland)
J. Waskowska M.D., Medical Univ. of Silesia (Poland)
A. Kawczyk-Krupka, Medical Univ. of Silesia (Poland)
A. Ledwon, Medical Univ. of Silesia (Poland)
A. Misiak, Medical Univ. of Silesia (Poland)
J. Waskowska M.D., Medical Univ. of Silesia (Poland)
A. Kawczyk-Krupka, Medical Univ. of Silesia (Poland)
A. Ledwon, Medical Univ. of Silesia (Poland)
A. Misiak, Medical Univ. of Silesia (Poland)
W. Latos, Medical Univ. of Silesia (Poland)
R. Koszowski M.D., Medical Univ. of Silesia (Poland)
K. Sieron-Stoltny, Medical Univ. of Silesia (Poland)
A. Sieron M.D., Medical Univ. of Silesia (Poland)
R. Koszowski M.D., Medical Univ. of Silesia (Poland)
K. Sieron-Stoltny, Medical Univ. of Silesia (Poland)
A. Sieron M.D., Medical Univ. of Silesia (Poland)
Published in SPIE Proceedings Vol. 6845:
Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XVII
David Kessel, Editor(s)
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