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Proceedings Paper

Laser-induced breakdown spectroscopy of whole blood and other liquid organic compounds
Author(s): N. Melikechi; H. Ding; S. Rock; A. Marcano O.; D. Connolly
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Paper Abstract

We report on laser-induced breakdown spectroscopy (LIBS) of whole blood and other organic fluids. LIBS spectra, in the region 200-970 nm, are measured by recording the radiation emitted by the samples following their ablation in a helium environment. We show that these spectra, although very complex, reveal the presence of elements such as nitrogen, hydrogen, oxygen and carbon and that of important metallic elements such as iron, magnesium, calcium, potassium, and sodium. We compare the measured LIBS spectra of whole blood to that of pure carbon and pure iron and find that in the 200-300 nm region. Nearly 90% of the peaks can be assigned to only these two elements. We also report on similar studies of methanol, ethanol, isopropanol and water solutions of protein molecules of interest to cancer research. We show that using simple numerical algorithms, it is possible to distinguish between complex organic compounds that have nearly the same chemical composition.

Paper Details

Date Published: 14 March 2008
PDF: 7 pages
Proc. SPIE 6863, Optical Diagnostics and Sensing VIII, 68630O (14 March 2008); doi: 10.1117/12.761901
Show Author Affiliations
N. Melikechi, Delaware State Univ. (United States)
H. Ding, Delaware State Univ. (United States)
S. Rock, Delaware State Univ. (United States)
A. Marcano O., Delaware State Univ. (United States)
D. Connolly, Fox Chase Cancer Ctr. (United States)

Published in SPIE Proceedings Vol. 6863:
Optical Diagnostics and Sensing VIII
Gerard L. Coté; Alexander V. Priezzhev, Editor(s)

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