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Proceedings Paper

Complex flow characterisation of a porous tissue scaffold measured by Doppler optical coherence tomography
Author(s): Peter H. Tomlins; Yiwei Wang; Bufa Zhang; Matthew Tedaldi; Paul E. Tomlins
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Paper Abstract

The flow of culture medium through a mechanically stimulated cell-seeded tissue scaffold is a factor influencing not only the transport of essential nutrients and waste product removal but also impacting on the degradation kinetics of the scaffold. Being able to map spatial and temporal changes in fluid flow behaviour is key to the development of improved bioreactors and tissue scaffold designs, especially for the new generation of multiple tissue reactors. In this paper we demonstrate the excellent metrological benefits of fast Doppler optical coherence tomography for time-lapse characterisation of tissue scaffolds placed in a dynamic flow environment.

Paper Details

Date Published: 6 February 2008
PDF: 8 pages
Proc. SPIE 6858, Optics in Tissue Engineering and Regenerative Medicine II, 685804 (6 February 2008); doi: 10.1117/12.761772
Show Author Affiliations
Peter H. Tomlins, National Physical Lab. (United Kingdom)
Yiwei Wang, National Physical Lab. (United Kingdom)
Bufa Zhang, National Physical Lab. (United Kingdom)
Matthew Tedaldi, National Physical Lab. (United Kingdom)
Paul E. Tomlins, National Physical Lab. (United Kingdom)

Published in SPIE Proceedings Vol. 6858:
Optics in Tissue Engineering and Regenerative Medicine II
Sean J. Kirkpatrick; Ruikang K. Wang, Editor(s)

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