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Proceedings Paper

Label-free detection of cytokines using optical microcavities
Author(s): Andrea M. Armani; Scott E. Fraser
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Paper Abstract

Ultra-high-Q microresonators have demonstrated sensitive and specific chemical and biological detection. The sensitivity is derived from the long photon lifetime inside the cavity and specificity is achieved through surface functionalization. Here, ultra-high-Q microcavities demonstrate label-free, single molecule detection of Interleukin-2 (IL-2) in fetal bovine serum (FBS). IL-2 is a cytokine released in response to immune system activation. The surface of the microtoroids was sensitized using anti-IL-2. The detection mechanism relies upon a thermo-optic mechanism to enhance resonant wavelength shifts induced through binding of a molecule.

Paper Details

Date Published: 21 February 2008
PDF: 11 pages
Proc. SPIE 6862, Single Molecule Spectroscopy and Imaging, 68620C (21 February 2008); doi: 10.1117/12.761002
Show Author Affiliations
Andrea M. Armani, California Institute of Technology (United States)
Scott E. Fraser, California Institute of Technology (United States)

Published in SPIE Proceedings Vol. 6862:
Single Molecule Spectroscopy and Imaging
Jörg Enderlein; Zygmunt K. Gryczynski; Rainer Erdmann, Editor(s)

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