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Proceedings Paper

Utility of micro-filter membrane in THz spectrum of molecules in solution
Author(s): H. Yoneyama; M. Yamashita; S. Kasai; H. Ito; T. Ouchi
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Paper Abstract

We report the experimental results of physiologically active substances including hormones utilizing Terahertz (THz) spectrum technology. Various analytical techniques have been employed for the determination of physiologically active substances. Most of methods used oxidation reagent and sodium sulfite stabilization reagent or fluorescent reagent. These methods had a good selectivity, but the stability of samples was not satisfactory. The direct detection method has not been advanced yet. In this study, the THz characteristics of physiologically active substances were measured directly. We found all of samples have their vibrational features like signature peaks either in pellet and/or sample solution. A membrane device was used to hold the sample solution in this study. This device allows samples to be prepared in solutions and measured easily with THz measurement system after dried. Results suggest that this membrane device is sensitive for detecting the physiologically active substances in THz ranges. THz spectrum technology has the potential to be a useful tool in clinical applications. This approach promotes the understanding of the relationships between biomolecules with THz radiation.

Paper Details

Date Published: 8 February 2008
PDF: 9 pages
Proc. SPIE 6853, Biomedical Optical Spectroscopy, 68530X (8 February 2008); doi: 10.1117/12.760850
Show Author Affiliations
H. Yoneyama, Terhertz Biological Sensing Research Lab., RIKEN (Japan)
M. Yamashita, Terhertz Biological Sensing Research Lab., RIKEN (Japan)
S. Kasai, Terhertz Biological Sensing Research Lab., RIKEN (Japan)
Canon Inc. (Japan)
H. Ito, Terhertz Biological Sensing Research Lab., RIKEN (Japan)
T. Ouchi, Terhertz Biological Sensing Research Lab., RIKEN (Japan)
Canon Inc. (Japan)

Published in SPIE Proceedings Vol. 6853:
Biomedical Optical Spectroscopy
Anita Mahadevan-Jansen; Robert R. Alfano; Alvin Katz; Wolfgang Petrich, Editor(s)

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