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Proceedings Paper

Pairing of homologous chromosomes as phase transition
Author(s): Antonio Scialdone; Mario Nicodemi
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Paper Abstract

In some cells pairing of homologous chromosomes happens at particular moments during the cell life cycle. A Statistical Mechanics model based on some experimental data is presented and discussed here for this phenomenon. Under this model, chromosomes pair at special regions whose interaction is mediated by some molecules which diffuse in cells' nuclei and can bind them. Concentration of these molecules acts as a switch for pairing: at low concentrations chromosomes move independently one from another whereas if concentration is above a certain threshold value, chromosomes colocalize. Monte Carlo simulations of this model have been performed to test its eficiency and the effect on pairing levels of chromosomal binding sites deletions.

Paper Details

Date Published: 11 January 2008
PDF: 7 pages
Proc. SPIE 6802, Complex Systems II, 68020F (11 January 2008); doi: 10.1117/12.759094
Show Author Affiliations
Antonio Scialdone, Univ. di Napoli Federico II (Italy)
Mario Nicodemi, Univ. of Warwick (United Kingdom)
INFN (Italy)

Published in SPIE Proceedings Vol. 6802:
Complex Systems II
Derek Abbott; Tomaso Aste; Murray Batchelor; Robert Dewar; Tiziana Di Matteo; Tony Guttmann, Editor(s)

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