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Proceedings Paper

Adenine detection by photonic crystal fiber based surface enhanced Raman scattering probe
Author(s): Mingshan Li; Changxi Yang; He Yan; Guofan Jin; Lantian Hou; Guiyao Zhou
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Paper Abstract

Detection of biological samples in low concentration is of great significance to the basic research in science, the development of medical technology and many other fields related to our lives. Surface-Enhanced Raman Scattering (SERS), well-known as a powerful analytical tool with high sensitivity, is especially suitable for biomolecule detection as it enables near infrared (NIR) excitation and label-free detection. SERS probe made of conventional optical fiber provides better flexibility in detection; however, it requires a complicated fabrication process and doesn't serve as a well-set detecting platform. In this talk we propose and demonstrate a photonic crystal fiber (PCF) based SERS probe, which has the new advantages of simplicity in fabrication, better light confinement and increased light-analyte interaction volume. The PCF-based SERS probes are prepared in three different ways: mixed solution of sample and gold nanoparticles filled in air holes of PCF, sample solution dried in gold coated air holes and sample solution filled in gold coated air holes, respectively. Sample solution of adenine is in concentration of about 10-6M. Almost every characteristic peak of adenine can be observed in the spectra detected by each of the three probes.

Paper Details

Date Published: 8 January 2008
PDF: 8 pages
Proc. SPIE 6838, Optoelectronic Devices and Integration II, 683802 (8 January 2008); doi: 10.1117/12.756903
Show Author Affiliations
Mingshan Li, Tsinghua Univ. (China)
Changxi Yang, Tsinghua Univ. (China)
He Yan, Tsinghua Univ. (China)
Guofan Jin, Tsinghua Univ. (China)
Lantian Hou, Yanshan Univ. (China)
Guiyao Zhou, Yanshan Univ. (China)

Published in SPIE Proceedings Vol. 6838:
Optoelectronic Devices and Integration II
Xuping Zhang; Hai Ming; Maggie Yihong Chen, Editor(s)

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