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Proceedings Paper

A self-normalized full time-resolved scheme for fluorescence diffuse optical tomography
Author(s): Feng Gao; Limin Zhang; Huiyuan He; Huijuan Zhao; Jingying Jiang; Yukari Tanikawa; Andhi Marjono; Yukio Yamada
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Paper Abstract

A full time-resolved scheme that has been previously applied in diffuse optical tomography is extended to time-domain fluorescence diffuse optical tomography regime, based on a finite-element-finite-time-difference photon diffusion modeling and a Newton-Raphson inversion framework. The merits of using full time-resolved data are twofold: it helps evaluate the intrinsic performance of time-domain mode for improvement of image quality and set up a 'gold standard' for the development of computationally efficient featured-data-based algorithms, and provides a self-normalized implementation to preclude the necessary for the scaling-factor calibration and spectroscopic-feature assessments of the system as well as to overcome the adversity of system instability. We validate the proposed methodology using simulated data, and evaluate its performances in simultaneously recovering the fluorescent yield and lifetime as well as its superiority to the featured-data one in the fidelity of image reconstruction.

Paper Details

Date Published: 20 February 2008
PDF: 12 pages
Proc. SPIE 6850, Multimodal Biomedical Imaging III, 68500N (20 February 2008); doi: 10.1117/12.756396
Show Author Affiliations
Feng Gao, Tianjin Univ. (China)
Limin Zhang, Tianjin Univ. (China)
Huiyuan He, Tianjin Univ. (China)
Huijuan Zhao, Tianjin Univ. (China)
Jingying Jiang, Tianjin Univ. (China)
Yukari Tanikawa, National Institute of Advanced Industrial Science and Technology (Japan)
Andhi Marjono, Univ. of Electro-Communications (Japan)
Yukio Yamada, Univ. of Electro-Communications (Japan)

Published in SPIE Proceedings Vol. 6850:
Multimodal Biomedical Imaging III
Fred S. Azar; Xavier Intes, Editor(s)

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