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Proceedings Paper

Effect of HMME-PDT with different parameters in rabbit ear model: a possible way for hypertrophic scarring
Author(s): Hong Cai; Ying Gu; Jing Zeng; Shao-ran Li; Qiang Sun; Ying Wang; Dong-wen Shi; Lu-yong Zhang
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Paper Abstract

Background and Objective: Hypertrophic scar is a pathological scar that grows aberrantly by excessive deposition of collagens in the dermis. It is known that photodynamic therapy (PDT) contributes to a variety of diseases, however, the use of inhibiting scar formation has not been fully explored. The purpose of this study is to investigate the effect of HMME-PDT (Photodynamic therapy induced by Hematoporphyrin Monomethyl Ether) with different parameters on hypertrophic scar in rabbit ear. Materials and Methods: After the placement of 7-mm diameter dermal wounds on each ear, the acute model of dermal hypertrophic scar in the New Zealand white rabbits was established. Scar wounds were randomly separated into 2 groups: the experimental group received HMME-PDT with different parameters, and the control group received no special treatment. Specimens were harvested from scar wounds on postoperative day 28. Scar and hypertrophic index (HI) were observed by haematoxylin-eosin staining. Results: Compared with the control group, scar formation was inhibited by HMME-PDT in the experimental group with parameters as follows: photosensitizer dose 10mg/kg, power density 20mw/cm2, fluence 5J/cm2, meanwhile, HI was decreased significantly. Conclusion: HMME-PDT may play a role in inhibiting hypertrophic scarring in rabbit ear. The biological effect is determined by the dose of photosensitizer, interval between the injection of photosensitizer and irradiation, power density and energy fluence.

Paper Details

Date Published: 8 January 2008
PDF: 8 pages
Proc. SPIE 6826, Optics in Health Care and Biomedical Optics III, 68262X (8 January 2008); doi: 10.1117/12.755801
Show Author Affiliations
Hong Cai, Chinese PLA General Hospital (China)
Ying Gu, Chinese PLA General Hospital (China)
Jing Zeng, Chinese PLA General Hospital (China)
Shao-ran Li, First Affiliated Hospital of General Hospital of PLA (China)
Qiang Sun, First Affiliated Hospital of General Hospital of PLA (China)
Ying Wang, Chinese PLA General Hospital (China)
Dong-wen Shi, Chinese PLA General Hospital (China)
Lu-yong Zhang, Chinese PLA General Hospital (China)

Published in SPIE Proceedings Vol. 6826:
Optics in Health Care and Biomedical Optics III
Xingde Li; Qingming Luo; Ying Gu M.D., Editor(s)

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