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Proceedings Paper

Nonlinear optical microscopy of bronchus
Author(s): Shuangmu Zhuo; Jianxin Chen; Xingshan Jiang; Shusen Xie; Huanglin Chen; Rong Chen
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Paper Abstract

As the first barrier exposed to carcinogens, the bronchus is prone to early pathologic alterations. The assessment of these early changes is of key significance in the physiological studies and disease diagnosis of bronchus. Here, we demonstrate nonlinear optical microscopy (NOLM) to image mouse bronchial wall microstructure based on intrinsic nonlinear optical contrast. Our results show that NOLM is effective for imaging the bronchial intact microstructural components, providing quantitatively information on the biomorphology and biochemistry of tissue. With the advent of the clinical portability of typical nonlinear optical endoscopy, the NOLM technique has the potential to be applied in vivo the clinical diagnosis and monitoring of bronchial disease.

Paper Details

Date Published: 8 January 2008
PDF: 6 pages
Proc. SPIE 6826, Optics in Health Care and Biomedical Optics III, 68261T (8 January 2008); doi: 10.1117/12.755221
Show Author Affiliations
Shuangmu Zhuo, Fujian Normal Univ. (China)
Jianxin Chen, Fujian Normal Univ. (China)
Xingshan Jiang, Fujian Normal Univ. (China)
Shusen Xie, Fujian Normal Univ. (China)
Huanglin Chen, Fujian Normal Univ. (China)
Rong Chen, Fujian Normal Univ. (China)

Published in SPIE Proceedings Vol. 6826:
Optics in Health Care and Biomedical Optics III
Xingde Li; Qingming Luo; Ying Gu M.D., Editor(s)

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