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Proceedings Paper

Physics and capabilities of terahertz spectroscopy to study the water-biomolecule interaction
Author(s): G. C. Vezzoli
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Paper Abstract

We have conducted the first study of the use of terahertz radiation to precisely identify pre-melting, melting, polymerization, depolymerization and the influence of polar water in sulfur by scanning frequency as a parametric function of temperature, and including identifying precursor and intermediate states. This spectroscopic study has also identified the orthorhombic-monoclinic phase transformation, and the melting of the superheated orthorhombic phase. This work also reports detection of a water absorption indicating a perturbation of the water molecules, associated with solvation spheres of the inter-chain dynamics, as a precursor to a transition, and supporting our earlier results showing the transducing capabilities of conglomerates of water molecules. Through a study of the fine structure of the water absorption, we are able to determine information about local polarization effects which contribute to the transducing properties of water relative to a ligand. The above inorganic polymer study is applied to the understanding of the response of biomolecules to thermal and chemical influences, and data are included giving optical, electrical, and pH properties of the DNA-water system, showing a major conformational transition at ~43°C, and various forms of reconformation of DNA macromolecule due to chemical perturbation. Our results include findings aimed at complementing existing inhibitors that are intended to prevent retrovirus/phage invasion of the host cell DNA.

Paper Details

Date Published: 28 September 2007
PDF: 13 pages
Proc. SPIE 6772, Terahertz Physics, Devices, and Systems II, 67720U (28 September 2007); doi: 10.1117/12.754472
Show Author Affiliations
G. C. Vezzoli, Vermont Photonics, LLC (United States)
Institute for the Basic Sciences (United States)

Published in SPIE Proceedings Vol. 6772:
Terahertz Physics, Devices, and Systems II
Mehdi Anwar; Anthony J. DeMaria; Michael S. Shur, Editor(s)

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