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Proceedings Paper

Three-dimensional image reconstruction for time-domain fluorescence molecular tomography based on generalized pulse spectrum technique
Author(s): Limin Zhang; Feng Gao; Huiyuan He; Yiwen Ma; Pingqiao Ruan; Huijuan Zhao
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Paper Abstract

A linear generalized pulse spectrum technique for image reconstruction of fluorescence molecular tomography is proposed. The algorithm employs a finite element method solution to the Laplace-transformed coupled diffusion equations and can simultaneously reconstruct both fluorescent yield and lifetime images of fluorophores. The proposed algorithm was validated using simulated data for 3D phantoms. We investigated the ability of the algorithm to reconstruct the fluorescent yield and lifetime at different region, contrasted the imaging quality of different target lifetime and proved the noise-robustness by using noisy data with different signal-to-noise ratio. The results show that the approach accurately retrieves the position and shape of the target and prove the effectiveness of the methodology.

Paper Details

Date Published: 8 January 2008
PDF: 8 pages
Proc. SPIE 6826, Optics in Health Care and Biomedical Optics III, 68262I (8 January 2008); doi: 10.1117/12.754070
Show Author Affiliations
Limin Zhang, Tianjin Univ. (China)
Feng Gao, Tianjin Univ. (China)
Huiyuan He, Tianjin Univ. (China)
Yiwen Ma, Tianjin Univ. (China)
Pingqiao Ruan, Tianjin Univ. (China)
Huijuan Zhao, Tianjin Univ. (China)

Published in SPIE Proceedings Vol. 6826:
Optics in Health Care and Biomedical Optics III
Xingde Li; Qingming Luo; Ying Gu M.D., Editor(s)

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