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Proceedings Paper

Induced movement of the magnetic beads and DNA-based dumbbell in a micro fluidic channel
Author(s): B. Babić; R. Ghai; K. Dimitrov
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Paper Abstract

We have explored controlled movement of magnetic beads and a dumbbell structure composed of DNA, a magnetic and a non-magnetic bead in a micro fluidic channel. Movement of the beads and dumbbells is simulated assuming that a net force is described as a superposition between the magnetic and hydrodynamic drag forces. Trajectories of beads and dumbbells are observed with optical light microscopy. The experimentally measured data show a good agreement with the simulations. This dynamical approach offers the prospect to stretch the DNA within the dumbbell and investigate its conformational changes. Further on, we demonstrate that short sonication can reduce multiple attachments of DNA to the beads.

Paper Details

Date Published: 27 December 2007
PDF: 6 pages
Proc. SPIE 6799, BioMEMS and Nanotechnology III, 67990U (27 December 2007); doi: 10.1117/12.753782
Show Author Affiliations
B. Babić, The Univ. of Queensland (Australia)
R. Ghai, The Univ. of Queensland (Australia)
K. Dimitrov, The Univ. of Queensland (Australia)

Published in SPIE Proceedings Vol. 6799:
BioMEMS and Nanotechnology III
Dan V. Nicolau; Derek Abbott; Kourosh Kalantar-Zadeh; Tiziana Di Matteo; Sergey M. Bezrukov, Editor(s)

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