
Proceedings Paper
Membranotropic photobiomodulation on red blood cell deformabilityFormat | Member Price | Non-Member Price |
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Paper Abstract
To assess modulation of laser on erythrocyte permeability and deformability via cell morphology changes, healthy
human echinocytes with shrinking size and high plasmic viscosity due to cellular dehydration were treated with 1 mW, 2
mW, 3 mW, and 5 mW laser power exposure respectively. Image analyzing system on single intact erythrocyte was
applied for measuring comprehensive cell morphological parameters (surface area, external membrane perimeter, circle
index and elongation index) that were determined by the modulation of erythrocyte water permeability and deformability
to detect relationship between erythrocyte water permeability alteration and deformability. Our preliminary experiment
showed that exposure under light dose of 5 mW for 5 min could induce more active erythrocyte swelling and
deformation. water channel aquaporin-1(AQP-1) was inhibited by the incubation of HgCl2 in the presence and absence of
5 mW laser irradiation. The result suggested that osmotic water permeability is a primary factor in the procedure of
erythrocyte deformability. In addition, no modulation of laser(5mW) on erythrocyte deformability had been found when
the echinocytes were cultured with GDP-β-S (G protein inhibitor).
Paper Details
Date Published: 1 May 2007
PDF: 11 pages
Proc. SPIE 6534, Fifth International Conference on Photonics and Imaging in Biology and Medicine, 653424 (1 May 2007); doi: 10.1117/12.741631
Published in SPIE Proceedings Vol. 6534:
Fifth International Conference on Photonics and Imaging in Biology and Medicine
Qingming Luo; Lihong V. Wang; Valery V. Tuchin; Min Gu, Editor(s)
PDF: 11 pages
Proc. SPIE 6534, Fifth International Conference on Photonics and Imaging in Biology and Medicine, 653424 (1 May 2007); doi: 10.1117/12.741631
Show Author Affiliations
Published in SPIE Proceedings Vol. 6534:
Fifth International Conference on Photonics and Imaging in Biology and Medicine
Qingming Luo; Lihong V. Wang; Valery V. Tuchin; Min Gu, Editor(s)
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