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Proceedings Paper

Investigation of glucose-hemoglobin interaction by optical coherence tomography
Author(s): Olga S. Zhernovaya; Alexey N. Bashkatov; Elina A. Genina; Valery V. Tuchin; Igor V. Meglinski; Dmitry Yu. Churmakov; Laurie J. Ritchie
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Paper Abstract

In this study, the refractive index of glucose-hemoglobin solutions at different glucose concentrations was measured. Measurements were performed using Abbe refractometer at 589 nm and OCT system at 1300 nm. The different amount of glucose was added to hemoglobin solution. Theoretical values of refractive index of the glucose-hemoglobin solutions were calculated in assumption that hemoglobin and glucose molecules do not interact. The difference between the measured and calculated values of refractive index can be connected with glucose binding to hemoglobin. It is shown that the refractive index measurements can be applied to the evaluation of glycated hemoglobin amount.

Paper Details

Date Published: 26 April 2007
PDF: 7 pages
Proc. SPIE 6535, Saratov Fall Meeting 2006: Optical Technologies in Biophysics and Medicine VIII, 65351C (26 April 2007); doi: 10.1117/12.740985
Show Author Affiliations
Olga S. Zhernovaya, Saratov State Univ. (Russia)
Alexey N. Bashkatov, Saratov State Univ. (Russia)
Elina A. Genina, Saratov State Univ. (Russia)
Valery V. Tuchin, Saratov State Univ. (Russia)
Igor V. Meglinski, Cranfield Univ. (United Kingdom)
Dmitry Yu. Churmakov, Cranfield Univ. (United Kingdom)
Laurie J. Ritchie, Cranfield Univ. (United Kingdom)

Published in SPIE Proceedings Vol. 6535:
Saratov Fall Meeting 2006: Optical Technologies in Biophysics and Medicine VIII
Valery V. Tuchin, Editor(s)

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