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Proceedings Paper

Interaction of a dual-wavelength laser system with cutaneous blood vessels
Author(s): Boris Majaron; Matija Milanič; J. Stuart Nelson
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Paper Abstract

Our working hypothesis is that a dual-wavelength Nd:YAG laser, emitting simultaneously at 1064 and 532 nm, may induce stronger heating of PWS blood vessels relative to the epidermis than the customary KTP laser, due to conversion of hemoglobin to met-hemoglobin in the target blood vessels and the associated increase in NIR absorption. We apply pulsed photothermal radiometry to determine temperature depth profiles induced in PWS lesions by a dual-wavelength laser at sub-therapeutic radiant exposures. The results indicate no effect at 1 ms pulse duration and low radiant exposures (1-2 J/cm2). Increased radiant exposure (3-4 J/cm2) and extended pulse duration (20-25 ms) result in increased energy deposition. In addition, two PWS lesions and one healthy skin site were irradiated at incrementally increasing radiant exposures, up to 9 J/cm2. Analysis of the laser-induced temperature profiles clearly revealed irreversible changes of tissue properties. Formation of met-hemoglobin and consequent increase of IR absorption was however not reliably detected.

Paper Details

Date Published: 13 July 2007
PDF: 12 pages
Proc. SPIE 6632, Therapeutic Laser Applications and Laser-Tissue Interactions III, 66320C (13 July 2007); doi: 10.1117/12.728457
Show Author Affiliations
Boris Majaron, Jožef Stefan Institute (Slovenia)
Beckman Laser Institute and Medical Clinic (United States)
Matija Milanič, Jožef Stefan Institute (Slovenia)
J. Stuart Nelson, Beckman Laser Institute and Medical Clinic (United States)
Univ. of California, Irvine (United States)

Published in SPIE Proceedings Vol. 6632:
Therapeutic Laser Applications and Laser-Tissue Interactions III
Alfred Vogel, Editor(s)

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