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Proceedings Paper

Real time diffuse reflectance polarisation spectroscopy imaging to evaluate skin microcirculation
Author(s): Jim O'Doherty; Joakim Henricson; Gert E. Nilsson; Chris Anderson; Martin J. Leahy
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Paper Abstract

This article describes the theoretical development and design of a real-time microcirculation imaging system, an extension from a previously technology developed by our group. The technology utilises polarisation spectroscopy, a technique used in order to selectively gate photons returning from various compartments of human skin tissue, namely from the superficial layers of the epidermis, and the deeper backscattered light from the dermal matrix. A consumer-end digital camcorder captures colour data with three individual CCDs, and a custom designed light source consisting of a 24 LED ring light provides broadband illumination over the 400 nm - 700 nm wavelength region. Theory developed leads to an image processing algorithm, the output of which scales linearly with increasing red blood cell (RBC) concentration. Processed images are displayed online in real-time at a rate of 25 frames s-1, at a frame size of 256 x 256 pixels, and is limited only by computer RAM memory and processing speed. General demonstrations of the technique in vivo display several advantages over similar technology.

Paper Details

Date Published: 18 July 2007
PDF: 10 pages
Proc. SPIE 6631, Novel Optical Instrumentation for Biomedical Applications III, 66310O (18 July 2007); doi: 10.1117/12.728337
Show Author Affiliations
Jim O'Doherty, Univ. of Limerick (Ireland)
Joakim Henricson, Univ. Hospital, Linköping (Sweden)
Gert E. Nilsson, Linköping Univ. (Sweden)
WheelsBridge AB (Sweden)
Chris Anderson, Univ. Hospital, Linköping (Sweden)
Martin J. Leahy, Univ. of Limerick (Ireland)

Published in SPIE Proceedings Vol. 6631:
Novel Optical Instrumentation for Biomedical Applications III
Christian D. Depeursinge, Editor(s)

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