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Proceedings Paper

Ophthalmic drug delivery utilizing two-photon absorption: a novel approach to treat posterior capsule opacification
Author(s): H.-C. Kim; J. Träger; M. Zorn; N. Haberkorn; N. Hampp
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Paper Abstract

Intraocular lens (IOL) implantation is the standard technique to treat cataract. Despite recent progress in surgical procedures, posterior capsule opacification is one of the sill remaining postoperative complications of cataract surgery. We present a novel strategy to reduce the incidence of posterior capsule opacification. A drug delivery polymer suitable for manufacturing intraocular lenses has been developed which enables repeated drug release in a non-invasive and controlled manner. The therapeutic molecules are attached through a UV light sensitive linkage to the polymer backbone which is mainly responsible for the optical properties of the intraocular lenses. However, UV light can not trigger the release of drug from the polymer due to the high absorption of the cornea. We developed linkers which enable drug release by two-photon absorption induced cleavage of the linker structure. Since the two-photon absorption requires high photon densities, this does not occur in ambient light conditions in daily life, but is easily triggered by focused laser beams from a pulsed laser. In this proof-of-principle study we have employed a cyclobutane type linker and investigated the properties of the therapeutic system with the approved drugs 5-fluorouracil and chlorambucil. The controlled drug delivery was successfully demonstrated in vitro and additional cell tests confirmed that the device itself shows no cytotoxicity until photochemical activation. This presented concept can provide a powerful method in ophthalmic drug delivery.

Paper Details

Date Published: 13 July 2007
PDF: 8 pages
Proc. SPIE 6632, Therapeutic Laser Applications and Laser-Tissue Interactions III, 66321E (13 July 2007); doi: 10.1117/12.728279
Show Author Affiliations
H.-C. Kim, Univ. of Marburg (Germany)
J. Träger, Univ. of Marburg (Germany)
M. Zorn, Univ. of Marburg (Germany)
N. Haberkorn, Univ. of Marburg (Germany)
N. Hampp, Univ. of Marburg (Germany)
Material Sciences Ctr., Marburg (Germany)

Published in SPIE Proceedings Vol. 6632:
Therapeutic Laser Applications and Laser-Tissue Interactions III
Alfred Vogel, Editor(s)

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