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Proceedings Paper

Optical tomographic imaging of activation of the infant auditory cortex using perturbation Monte Carlo with anatomical a priori information
Author(s): Juha Heiskala; Kalle Kotilahti; Lauri Lipiäinen; Petri Hiltunen; P. Ellen Grant M.D.; Ilkka Nissilä
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Paper Abstract

We have developed a perturbation Monte Carlo method for calculating forward and inverse solutions to the optical tomography imaging problem in the presence of anatomical a priori information. The method uses frequency domain data. In the present work, we consider the problem of imaging hemodynamic changes due to brain activation in the infant brain. We test finite element method and Monte Carlo based implementations using a homogeneous model with the exterior of the domain warped to match digitized points on the skin. With the perturbation Monte Carlo model, we also test a heterogeneous model based on anatomical a priori information derived from a previously recorded infant T1 magnetic resonance (MR) image. Our simulations show that the anatomical information improves the accuracy of reconstructions quite significantly even if the anatomical MR images are based on another infant. This suggests that significant benefits can be obtained by the use of generic infant brain atlas information in near-infrared spectroscopy and optical tomography studies.

Paper Details

Date Published: 12 July 2007
PDF: 11 pages
Proc. SPIE 6629, Diffuse Optical Imaging of Tissue, 66290T (12 July 2007); doi: 10.1117/12.728276
Show Author Affiliations
Juha Heiskala, Helsinki Univ. Central Hospital (Finland)
Helsinki Univ. of Technology (Finland)
Univ. of Helsinki (Finland)
Kalle Kotilahti, Helsinki Univ. of Technology (Finland)
Univ. of Helsinki (Finland)
Lauri Lipiäinen, Helsinki Univ. of Technology (Finland)
Univ. of Helsinki (Finland)
Petri Hiltunen, Helsinki Univ. of Technology (Finland)
Univ. of Helsinki (Finland)
P. Ellen Grant M.D., Massachusetts General Hospital (United States)
Ilkka Nissilä, Helsinki Univ. of Technology (Finland)
Univ. of Helsinki (Finland)

Published in SPIE Proceedings Vol. 6629:
Diffuse Optical Imaging of Tissue
Brian W. Pogue; Rinaldo Cubeddu, Editor(s)

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