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Proceedings Paper

Correlation between direct microscopy and FDG-PET in the study of cerebral blood flow in rats
Author(s): Oleg Blagosklonov; Guennady I. Podoprigora; Sergey V Pushkin; Yaroslav R.. Nartsissov; Laurent Comas; Jean-Claude Cardot; Hatem Boulahdour
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Paper Abstract

Isotope studies provide valuable data about an organ's function in vivo. Thanks to positron emission tomography (PET) using the radiolabeled natural metabolites, such as [18F]-2-fluoro-deoxy-d-glucose (FDG), biological and physiological meaning of nuclear medicine scans has been considerably increased. Therefore it is of interest to elucidate the possibilities of the technique in a study of some natural metabolites like glycine influencing the blood microcirculation. Glycine, as a medicine, was recently shown to have a positive therapeutic effect in the treatment of patients with ischemic stroke and some other neurological disorders based on vascular disturbances. By previous direct biomicroscopic investigations of pial microvessels in laboratory rats an expressed vasodilatory effect of topically applied glycine was proved. The arterioles diameters depending on initial size have been increased by 200-250% for arterioles of 20-40 μm and by 150-200% for arterioles of 50-80 μm. The PET images were acquired before and after sublingual application of glycine (200 mg). The quantitative analysis of FDG volume concentration (Bq/ml) in the rat brain demonstrated that, in studies after glycine administration, maximal, minimal and mean FDG volume concentration in the brain increased by 200-250% in comparison with the baseline data. Thus, our results revealing evident correlation between FDG-PET images and direct biomicroscopic observations confirm the great potential of molecular imaging techniques to explore in vivo process in the brain.

Paper Details

Date Published: 11 July 2007
PDF: 5 pages
Proc. SPIE 6626, Molecular Imaging, 66260P (11 July 2007); doi: 10.1117/12.727945
Show Author Affiliations
Oleg Blagosklonov, Jean Minjoz Univ. Hospital and Univ. de Franche-Comté (France)
Guennady I. Podoprigora, Institute of Cytochemistry-Molecular Pharmacology (Russia)
Sergey V Pushkin, Institute of Cytochemistry-Molecular Pharmacology (Russia)
Yaroslav R.. Nartsissov, Institute of Cytochemistry-Molecular Pharmacology (Russia)
Laurent Comas, Jean Minjoz Univ. Hospital and Univ. de Franche-Comté (France)
Jean-Claude Cardot, Jean Minjoz Univ. Hospital and Univ. de Franche-Comté (France)
Hatem Boulahdour, Jean Minjoz Univ. Hospital and Univ. de Franche-Comté (France)

Published in SPIE Proceedings Vol. 6626:
Molecular Imaging
Kai Licha; Vasilis Ntziachristos, Editor(s)

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