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Proceedings Paper

Optical spectroscopic studies of animal skin used in modeling of human cutaneous tissue
Author(s): E. Drakaki; M. Makropoulou; A. A. Serafetinides; E. Borisova; L. Avramov; J. A. Sianoudis
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Paper Abstract

Optical spectroscopy and in particular laser-induced autofluorescence spectroscopy (LIAFS) and diffuse reflectance spectroscopy (DRS), provide excellent possibilities for real-time, noninvasive diagnosis of different skin tissue pathologies. However, the introduction of optical spectroscopy in routine medical practice demands a statistically important data collection, independent from the laser sources and detectors used. The scientists collect databases either from patients, in vivo, or they study different animal models to obtain objective information for the optical properties of various types of normal and diseased tissue. In the present work, the optical properties (fluorescence and reflectance) of two animal skin models are investigated. The aim of using animal models in optical spectroscopy investigations is to examine the statistics of the light induced effects firstly on animals, before any extrapolation effort to humans. A nitrogen laser (&lgr;=337.1 nm) was used as an excitation source for the autofluorescence measurements, while a tungsten-halogen lamp was used for the reflectance measurements. Samples of chicken and pig skin were measured in vitro and were compared with results obtained from measurements of normal human skin in vivo. The specific features of the measured reflectance and fluorescence spectra are discussed, while the limits of data extrapolation for each skin type are also depicted.

Paper Details

Date Published: 13 March 2007
PDF: 5 pages
Proc. SPIE 6604, 14th International School on Quantum Electronics: Laser Physics and Applications, 66042K (13 March 2007); doi: 10.1117/12.727723
Show Author Affiliations
E. Drakaki, National Technical Univ. of Athens (Greece)
M. Makropoulou, National Technical Univ. of Athens (Greece)
A. A. Serafetinides, National Technical Univ. of Athens (Greece)
E. Borisova, Institute of Electronics (Bulgaria)
L. Avramov, Institute of Electronics (Bulgaria)
J. A. Sianoudis, Technological Educational Institution of Athens (Greece)

Published in SPIE Proceedings Vol. 6604:
14th International School on Quantum Electronics: Laser Physics and Applications
Peter A. Atanasov; Tanja N. Dreischuh; Sanka V. Gateva; Lubomir M. Kovachev, Editor(s)

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