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Proceedings Paper

Simultaneous surface and volume registration using harmonic maps
Author(s): Anand A. Joshi; David W. Shattuck; Paul M. Thompson; Richard M. Leahy
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Paper Abstract

Inter-subject analysis of anatomical and functional brain imaging data requires the images to be registered to a common coordinate system in which anatomical features are aligned. Intensity-based volume registration methods can align subcortical structures well, but the variability in sulcal folding patterns typically results in misalignment of the cortical surface. Conversely, surface-based registration using sulcal features can produce excellent cortical alignment but the mapping between brains is restricted to the cortical surface. Here we describe a method for volumetric registration that also produces a one-to-one point correspondence between cortical surfaces. This is achieved by first parameterizing and aligning the cortical surfaces. We then use a constrained harmonic mapping to define a volumetric correspondence between brains. Finally, the correspondence is refined using an intensity-based warp. We evaluate the performance of our proposed method in terms of the inter-subject alignment of expert-labeled sub-cortical structures after registration.

Paper Details

Date Published: 28 February 2007
PDF: 12 pages
Proc. SPIE 6498, Computational Imaging V, 649816 (28 February 2007); doi: 10.1117/12.718137
Show Author Affiliations
Anand A. Joshi, Univ. of Southern California (United States)
David W. Shattuck, Univ. of California, Los Angeles (United States)
Paul M. Thompson, Univ. of California, Los Angeles (United States)
Richard M. Leahy, Univ. of Southern California (United States)

Published in SPIE Proceedings Vol. 6498:
Computational Imaging V
Charles A. Bouman; Eric L. Miller; Ilya Pollak, Editor(s)

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