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Proceedings Paper

Whole-body subcellular multicolor imaging
Author(s): Meng Yang; Ping Jiang; Robert M. Hoffman
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Paper Abstract

An important goal for in vivo imaging is to be able to non-invasively image single cells. The Olympus IV100 Laser Scanning Microscope, with ultra-thin microscope objectives ("stick objectives"), was used for three-color whole-body imaging of individual two-color cancer cells interacting with the GFP-expressing stromal cells. Cellular dynamics were non-invasively imaged including mitotic and apoptotic tumor cells, stromal cells interacting with the tumor cells, tumor vasculature, and tumor blood flow. This imageable model should lead to a new paradigm of in vivo cancer cell biology and to new visible real-time targets for cancer drug discovery.

Paper Details

Date Published: 3 February 2007
PDF: 9 pages
Proc. SPIE 6449, Genetically Engineered and Optical Probes for Biomedical Applications IV, 64490V (3 February 2007); doi: 10.1117/12.714035
Show Author Affiliations
Meng Yang, AntiCancer, Inc. (United States)
Ping Jiang, AntiCancer, Inc. (United States)
Robert M. Hoffman, AntiCancer, Inc. (United States)
Univ. of California, San Diego (United States)

Published in SPIE Proceedings Vol. 6449:
Genetically Engineered and Optical Probes for Biomedical Applications IV
Samuel Achilefu; Alexander Pavlovich Savitsky; Rebekka M. Wachter; Darryl J. Bornhop; Ramesh Raghavachari, Editor(s)

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