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Proceedings Paper

Elemental spectrum of a mouse obtained via neutron stimulation
Author(s): Amy C. Sharma; Georgia D. Tourassi; Anuj J. Kapadia; Alexander S. Crowell; Matthew R. Kiser; Anthony Hutcheson; Brian P. Harrawood; Calvin R. Howell; Carey E. Floyd Jr.
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Paper Abstract

Several studies have shown that the concentration of certain elements may be a disease indicator. We are developing a spectroscopic imaging technique, Neutron Stimulated Emission Computed Tomography (NSECT), to non-invasively measure and image elemental concentrations within the body. The region of interest is interrogated via a beam of high-energy neutrons that excite elemental nuclei through inelastic scatter. These excited nuclei then relax by emitting characteristic gamma radiation. Acquiring the gamma energy spectrum in a tomographic geometry allows reconstruction of elemental concentration images. Our previous studies have demonstrated NSECT's ability to obtain spectra and images of known elements and phantoms, as well as, initial interrogations of biological tissue. Here, we describe the results obtained from NSECT interrogation of a fixed mouse specimen. The specimen was interrogated via a 5MeV neutron beam for 9.3 hours in order to ensure reasonable counting statistics. The gamma energy spectrum was obtained using two High-Purity Germanium (HPGe) clover detectors. A background spectrum was obtained by interrogating a specimen container containing 50mL of 0.9% NaCl solution. Several elements of biological interest including 12C, 40Ca, 31P, and 39K were identified with greater then 90% confidence. This interrogation demonstrates the feasibility of NSECT interrogation of small animals. Interrogation with a commercial neutron source that provides higher neutron flux and lower energy (~2.5MeV) neutrons would reduce scanning time and eliminate background from certain elements.

Paper Details

Date Published: 16 March 2007
PDF: 8 pages
Proc. SPIE 6510, Medical Imaging 2007: Physics of Medical Imaging, 65100K (16 March 2007); doi: 10.1117/12.713731
Show Author Affiliations
Amy C. Sharma, Duke Univ. (United States)
Duke Univ. Medical Ctr. (United States)
Georgia D. Tourassi, Duke Univ. Medical Ctr. (United States)
Anuj J. Kapadia, Duke Univ. (United States)
Duke Univ. Medical Ctr. (United States)
Alexander S. Crowell, Triangle Univs. Nuclear Lab., Duke Univ. (United States)
Matthew R. Kiser, Triangle Univs. Nuclear Lab., Duke Univ. (United States)
Anthony Hutcheson, Triangle Univs. Nuclear Lab., Duke Univ. (United States)
Brian P. Harrawood, Duke Univ. Medical Ctr. (United States)
Calvin R. Howell, Triangle Univs. Nuclear Lab., Duke Univ. (United States)
Carey E. Floyd Jr., Duke Univ. (United States)
Duke Univ. Medical Ctr. (United States)


Published in SPIE Proceedings Vol. 6510:
Medical Imaging 2007: Physics of Medical Imaging
Jiang Hsieh; Michael J. Flynn, Editor(s)

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