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Proceedings Paper

Development and implementation of a high-performance cardiac-gated dual-energy imaging system
Author(s): N. A. Shkumat; J. H. Siewerdsen; A. C. Dhanantwari; D. B. Williams; S. Richard; D. J Tward; N. S. Paul; J. Yorkston; R. Van Metter
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Paper Abstract

Mounting evidence suggests that the superposition of anatomical clutter in a projection radiograph poses a major impediment to the detectability of subtle lung nodules. Through decomposition of projections acquired at multiple kVp, dual-energy (DE) imaging offers to dramatically improve lung nodule detectability and, in part through quantitation of nodule calcification, increase specificity in nodule characterization. The development of a high-performance DE chest imaging system is reported, with design and implementation guided by fundamental imaging performance metrics. A diagnostic chest stand (Kodak RVG 5100 digital radiography system) provided the basic platform, modified to include: (i) a filter wheel, (ii) a flat-panel detector (Trixell Pixium 4600), (iii) a computer control and monitoring system for cardiac-gated acquisition, and (iv) DE image decomposition and display. Computational and experimental studies of imaging performance guided optimization of key acquisition technique parameters, including: x-ray filtration, allocation of dose between low- and high-energy projections, and kVp selection. A system for cardiac-gated acquisition was developed, directing x-ray exposures to within the quiescent period of the heart cycle, thereby minimizing anatomical misregistration. A research protocol including 200 patients imaged following lung nodule biopsy is underway, allowing preclinical evaluation of DE imaging performance relative to conventional radiography and low-dose CT.

Paper Details

Date Published: 20 March 2007
PDF: 12 pages
Proc. SPIE 6510, Medical Imaging 2007: Physics of Medical Imaging, 651006 (20 March 2007); doi: 10.1117/12.713680
Show Author Affiliations
N. A. Shkumat, Univ. of Toronto (Canada)
J. H. Siewerdsen, Univ. of Toronto (Canada)
Ontario Cancer Institute (Canada)
A. C. Dhanantwari, Ontario Cancer Institute (Canada)
D. B. Williams, Ontario Cancer Institute (Canada)
S. Richard, Univ. of Toronto (Canada)
D. J Tward, Univ. of Toronto (Canada)
N. S. Paul, Princess Margaret Hospital (Canada)
J. Yorkston, Eastman Kodak Co. (United States)
R. Van Metter, Eastman Kodak Co. (United States)

Published in SPIE Proceedings Vol. 6510:
Medical Imaging 2007: Physics of Medical Imaging
Jiang Hsieh; Michael J. Flynn, Editor(s)

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