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Proceedings Paper

Iodine contrast cone-beam CT imaging of breast cancer
Author(s): Larry Partain; Stavros Prionas; Edward Seppi; Gary Virshup; Gerhard Roos; Robert Sutherland; John Boone
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Paper Abstract

An iodine contrast agent, in conjunction with an X-ray cone beam CT imaging system, was used to clearly image three, biopsy verified, cancer lesions in two patients. The lesions were approximately in the 10 mm to 6 mm diameter range. Additional regions were also enhanced with approximate dimensions down to 1 mm or less in diameter. A flat panel detector, with 194 μm pixels in 2 x 2 binning mode, was used to obtain 500 projection images at 30 fps with an 80 kVp X-ray system operating at 112 mAs, for an 8-9 mGy dose - equivalent to two view mammography for these women. The patients were positioned prone, while the gantry rotated in the horizontal plane around the uncompressed, pendant breasts. This gantry rotated 360 degrees during the patient's 16.6 sec breath hold. A volume of 100 cc of 320 mg/ml iodine-contrast was power injected at 4 cc/sec, via catheter into the arm vein of the patient. The resulting 512 x 512 x 300 cone beam CT data set of Feldkamp reconstructed ~(0.3 mm)3 voxels were analyzed. An interval of voxel contrast values, characteristic of the regions with iodine contrast enhancement, were used with surface rendering to clearly identify up to a total of 13 highlighted volumes. This included the three largest lesions, that were previously biopsied and confirmed to be malignant. The other ten highlighted regions, of smaller diameters, are likely areas of increased contrast trapping unrelated to cancer angiogenesis. However the technique itself is capable of resolving lesions that small.

Paper Details

Date Published: 14 March 2007
PDF: 8 pages
Proc. SPIE 6510, Medical Imaging 2007: Physics of Medical Imaging, 65102U (14 March 2007); doi: 10.1117/12.713637
Show Author Affiliations
Larry Partain, Varian Medical Systems (United States)
Stavros Prionas, Varian Medical Systems (United States)
Edward Seppi, Varian Medical Systems (United States)
Gary Virshup, Varian Medical Systems (United States)
Gerhard Roos, Varian Medical Systems (United States)
Robert Sutherland, Varian Medical Systems (United States)
John Boone, UC Davis Medical Ctr. (United States)

Published in SPIE Proceedings Vol. 6510:
Medical Imaging 2007: Physics of Medical Imaging
Jiang Hsieh; Michael J. Flynn, Editor(s)

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