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Proceedings Paper

Longitudinal vascular imaging using a novel nano-encapsulated CT and MR contrast agent
Author(s): Jinzi Zheng; Jeremy D. Hoisak; Christine Allen; David A. Jaffray
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Paper Abstract

Contrast agents are widely employed in medical imaging for improved visualization of anatomy and disease characterization. In recent years, there is increasing interest in developing novel contrast agents and using their tissue accumulation and clearance patterns to obtain physiological information. The goal of this investigation is to assess the utility of a long circulating dual modality liposomal contrast agent for longitudinal imaging applications in computed tomography (CT) and magnetic resonance (MR) imaging. It was demonstrated that this high molecular weight contrast agent is retained in healthy vasculature (circulation half-life of ~20 hours in mice and ~100 hours in rabbits), but it is able to leak through abnormal tumor vasculature into the tumor interstitium. The rate of its differential tumor uptake was monitored in CT and MR longitudinally over a 48-hour period and a map of the rate of change of contrast enhancement was produced. This contrast agent has shown potential for anatomic and physiological imaging of healthy and abnormal blood vessels in CT and MR. It may become a useful tool for tumor vasculature assessment before, during and after antitumor treatments.

Paper Details

Date Published: 29 March 2007
PDF: 9 pages
Proc. SPIE 6511, Medical Imaging 2007: Physiology, Function, and Structure from Medical Images, 65111D (29 March 2007); doi: 10.1117/12.711535
Show Author Affiliations
Jinzi Zheng, Univ. of Toronto (Canada)
Jeremy D. Hoisak, Univ. of Toronto (Canada)
Christine Allen, Univ. of Toronto (Canada)
David A. Jaffray, Univ.of Toronto (Canada)
Princess Margaret Hospital (Canada)

Published in SPIE Proceedings Vol. 6511:
Medical Imaging 2007: Physiology, Function, and Structure from Medical Images
Armando Manduca; Xiaoping P. Hu, Editor(s)

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