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Proceedings Paper

3D bioluminescent source localization of different depths with spectrum information and adaptive finite element analysis
Author(s): Yujie Lv; Jie Tian; Wenxiang Cong; Ge Wang; Wei Yang; Min Xu
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Paper Abstract

In this contribution, a novel adaptive finite element based source localization method is proposed and developed, which adopts the spectrum characteristic of bioluminescent source. In this method, multiple sets of surface measured data corresponding to the discretized spectral bands reduce the ill-posedness of BLT. Then, the adaptive mesh refinement using a posteriori error estimation helps not only to avoid the dimension disaster arisen from the multi-spectral measured data, but also to improve the BLT reconstruction. In addition, a posteriori permissible source region selection further reduces the ill-posedness of BLT and enhances the reconstruction stability and speed. Finally, the simulation verification of the proposed method is performed with the Monte Carlo (MC) based synthetic data. The accurate localization of one and two bioluminescent sources in different depths shows the effectiveness and potential of this algorithm for BLT.

Paper Details

Date Published: 13 March 2007
PDF: 8 pages
Proc. SPIE 6510, Medical Imaging 2007: Physics of Medical Imaging, 651025 (13 March 2007); doi: 10.1117/12.709018
Show Author Affiliations
Yujie Lv, Institute of Automation (China)
Jie Tian, Institute of Automation (China)
Wenxiang Cong, Virginia Polytechnic Institute and State Univ. (United States)
Ge Wang, Virginia Polytechnic Institute and State Univ. (United States)
Wei Yang, Institute of Automation (China)
Min Xu, Institute of Automation (China)

Published in SPIE Proceedings Vol. 6510:
Medical Imaging 2007: Physics of Medical Imaging
Jiang Hsieh; Michael J. Flynn, Editor(s)

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