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Proceedings Paper

The effect of image quality on the appearance of lesions on breast ultrasound: implications for CADx
Author(s): Karen Drukker; Charlene A. Sennett; Maryellen L. Giger
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Paper Abstract

With the emergence of recent technology in breast ultrasound, sonographic image quality has changed profoundly. Most notably, the technique of real-time spatial compounding impacts the appearance of lesions and parenchyma. During image acquisition, spatial compounding can be turned on or off at the discretion of the radiologist, but this information is not stored along with the image data. The ability to distinguishing between lesions imaged with and without spatial compounding, using either single image features or a Bayesian neural net (BNN), was assessed using ROC analysis. Our database consisted of consecutively collected HDI5000 images of 129 lesions imaged without spatial compounding (357 images, cancer prevalence of 18%) and 370 lesions imaged with spatial compounding (965 images, cancer prevalence 15%). These were used in automated feature selection and BNN training. An additional 33 lesions were imaged for which identical views with and without spatial compounding were available (70 images, cancer prevalence 15%). These served as an independent test dataset. Lesions were outlined by a radiologist and image features, mathematically describing lesion characteristics, were calculated. In feature selection, the 4 best performing features were related to gradient strength and entropy. The average gradient strength within a lesion obtained an area under the ROC curve (AUC) of 0.78 in the task of distinguishing lesions imaged with and without spatial compounding. The BNN, using 4 features, achieved an AUC on the independent test dataset of 0.98 in this task. The sonographic appearance of breast lesions is affected by spatial compound imaging and lesion features may be used to automatically separate images as obtained with or without this technique. In computer-aided diagnosis (CADx), it will likely be beneficial to separate images as such before using separate classifiers for assessment of malignancy.

Paper Details

Date Published: 29 March 2007
PDF: 8 pages
Proc. SPIE 6514, Medical Imaging 2007: Computer-Aided Diagnosis, 65141E (29 March 2007);
Show Author Affiliations
Karen Drukker, Univ. of Chicago (United States)
Charlene A. Sennett, Univ. of Chicago (United States)
Maryellen L. Giger, Univ. of Chicago (United States)

Published in SPIE Proceedings Vol. 6514:
Medical Imaging 2007: Computer-Aided Diagnosis
Maryellen L. Giger; Nico Karssemeijer, Editor(s)

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