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Proceedings Paper

Functional thermal lens microscopes for ultrasensitive analysis of non-fluorescent molecules and microchip chemistry
Author(s): Kazuma Mawatari; Takehiko Kitamori
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Paper Abstract

Thermal lens microscope (TLM) is a kind of absorption spectrophotometry based on photothermal phenomena of non-fluorescent molecules. TLM has high sensitivity (single molecule concentration in fL detection volume) and wide applicability (non-fluorescent molecules). TLM was successfully applied to detection on microchip in clinical diagnosis, environmental analysis, single cell analysis and so on. The basic function of TLM is concentration determination in microspace. In addition, we have realized various functions on TLM for sensitive chiral analysis, individual nanoparticle counting and in situ flow sensing. In this presentation, we explain these functional TLMs for microchip chemistry.

Paper Details

Date Published: 8 September 2006
PDF: 7 pages
Proc. SPIE 6343, Photonics North 2006, 63430C (8 September 2006); doi: 10.1117/12.707488
Show Author Affiliations
Kazuma Mawatari, Kanagawa Academy of Science and Technology (Japan)
Takehiko Kitamori, Kanagawa Academy of Science and Technology (Japan)
The Univ. of Tokyo (Japan)

Published in SPIE Proceedings Vol. 6343:
Photonics North 2006
Pierre Mathieu, Editor(s)

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