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Proceedings Paper

Experimental investigation of target and transducer effects on quantitative image reconstruction in photoacoustic tomography
Author(s): John Gamelin; Andres Aguirre; Fei Huang; Anastasios Maurudis; Diego Castillo; Lihong V. Wang; Quing Zhu
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Paper Abstract

In principle, absorbed energy profiles can be exactly reconstructed from photoacoustic measurements on a closed surface. Clinical applications, however, involve compromises due to transducer focus, frequency characteristics, and incomplete measurement apertures. These tradeoffs introduce artifacts and errors in reconstructed absorption distributions that affect quantitative interpretations as well as qualitative contrast between features. The quantitative effects of target geometry, limited measurement surfaces, and bandpass transducer frequency response have been investigated using a ring transducer system designed for small animal imaging. The directionality of photoacoustic radiation is shown to increase with target aspect ratio, producing proportionate overestimates of absorption values for two-dimension apertures less than approximately 150 degrees. For all target geometries and orientations, mean absorption values approach the full view values for hemicircular measurement surfaces although the true spatial uniformity is recovered only with the complete surface. The bandpass transducer frequency spectrum produces a peaked amplitude response biased toward spatial features ranging from 1 to 8 times the system resolution. We discuss the implications of these results for design of clinical systems.

Paper Details

Date Published: 27 February 2007
PDF: 10 pages
Proc. SPIE 6437, Photons Plus Ultrasound: Imaging and Sensing 2007: The Eighth Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics, 64371F (27 February 2007); doi: 10.1117/12.707245
Show Author Affiliations
John Gamelin, Univ. of Connecticut (United States)
Andres Aguirre, Univ. of Connecticut (United States)
Fei Huang, Univ. of Connecticut (United States)
Anastasios Maurudis, Univ. of Connecticut (United States)
Diego Castillo, Univ. of Connecticut (United States)
Lihong V. Wang, Washington Univ., St. Louis (United States)
Quing Zhu, Univ. of Connecticut (United States)

Published in SPIE Proceedings Vol. 6437:
Photons Plus Ultrasound: Imaging and Sensing 2007: The Eighth Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics
Alexander A. Oraevsky; Lihong V. Wang, Editor(s)

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