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Proceedings Paper

Regional polarization sensitivity of articular cartilage by using polarization sensitive optical coherence tomography
Author(s): Tuqiang Xie; Shuguang Guo; Zhongping Chen; George M. Peavy
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Paper Abstract

In this study, PS-OCT is used to image fresh bovine joints to investigate the orientation of collagen fibrils in relation to optical phase retardation to better understand the distribution of normal matrix orientation and articular cartilage birefringence in different regions of a whole joint. Understanding and mapping variations in matrix organization and orientation within the normal joint is an important issue in potential applications of PS-OCT for evaluation and diagnosis of degenerative joint disease (DJD). The experimental results demonstrate that articular cartilage is not polarization sensitive on the edge of the medial, but polarization sensitive on the lateral edge of the tibial plateau. The collagen orientation on the edge of the joint is different from the central areas of the joint. Normal articular cartilage demonstrates regional polarization sensitivity within joints that is important to understand in order to accurately assess cartilage health by PS-OCT.

Paper Details

Date Published: 7 February 2007
PDF: 6 pages
Proc. SPIE 6429, Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine XI, 64292O (7 February 2007); doi: 10.1117/12.704226
Show Author Affiliations
Tuqiang Xie, Beckman Laser Institute (United States)
Shuguang Guo, Beckman Laser Institute (United States)
Zhongping Chen, Beckman Laser Institute (United States)
George M. Peavy, Beckman Laser Institute (United States)

Published in SPIE Proceedings Vol. 6429:
Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine XI
James G. Fujimoto; Joseph A. Izatt; Valery V. Tuchin, Editor(s)

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