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Proceedings Paper

Non-invasive monitoring of hemodynamic changes in orthotropic brain tumor
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Paper Abstract

Radio surgical interventions such as Gamma Knife and Cyberknife have become attractive as therapeutic interventions. However, one of the drawbacks of cyberknife is radionecrosis, which is caused by excessive radiation to surrounding normal tissues. Radionecrosis occurs in about 10-15% of cases and could have adverse effects leading to death. Currently available imaging techniques have failed to reliably distinguish radionecrosis from tumor growth. Development of imaging techniques that could provide distinction between tumor growth and radionecrosis would give us ability to monitor effects of radiation therapy non-invasively. This paper investigates the use of near infrared spectroscopy (NIRS) as a new technique to monitor the growth of brain tumors. Brain tumors (9L glioma cell line) were implanted in right caudate nucleus of rats (250-300 gms, Male Fisher C) through a guide screw. A new algorithm was developed, which used broadband steady-state reflectance measurements made using a single source-detector pair, to quantify absolute concentrations of hemoglobin derivatives and reduced scattering coefficients. Preliminary results from the brain tumors indicated decreases in oxygen saturation, oxygenated hemoglobin concentrations and increases in deoxygenated hemoglobin concentrations with tumor growth. The study demonstrates that NIRS technology could provide an efficient, noninvasive means of monitoring vascular oxygenation dynamics of brain tumors and further facilitate investigations of efficacy of tumor treatments.

Paper Details

Date Published: 13 February 2007
PDF: 7 pages
Proc. SPIE 6434, Optical Tomography and Spectroscopy of Tissue VII, 643408 (13 February 2007);
Show Author Affiliations
Dheerendra Kashyap, Univ. of Texas at Arlington (United States)
Univ. of Texas Southwestern Medical Ctr. at Dallas (United States)
Vikrant Sharma, Baylor Univ. Medical Ctr. at Dallas (United States)
Hanli Liu, Univ. of Texas at Arlington (United States)
Univ. of Texas Southwestern Medical Ctr. at Dallas (United States)

Published in SPIE Proceedings Vol. 6434:
Optical Tomography and Spectroscopy of Tissue VII
Britton Chance; Robert R. Alfano; Bruce J. Tromberg; Mamoru Tamura; Eva Marie Sevick-Muraca, Editor(s)

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