Share Email Print

Proceedings Paper

Microscopic x-ray imaging system for biomedical applications using synchrotron radiation
Author(s): Keiji Umetani; Makito Kobatake; Akira Yamamoto; Takenori Yamashita; Shigeki Imai
Format Member Price Non-Member Price
PDF $17.00 $21.00

Paper Abstract

An X-ray direct-conversion type detector with a spatial resolution of 10-11 &mgr;m was developed for real-time biomedical imaging. The detector incorporates the X-ray SATICON pickup tube with a photoconductive target layer of amorphous selenium. For high-resolution imaging, the X-ray image is directly converted into an electric signal in the photoconductive layer without image blur. Microangiography experiments were carried out for depicting angiogenic vessels in a rabbit model of cancer using the direct-conversion detector and a third generation synchrotron radiation source at SPring-8. In synchrotron radiation radiography, a long source-to-object distance and a small source spot can produce high-resolution images. After transplantation of cancer cells into the rabbit auricle, small tumor blood vessels with diameters of 20-30 &mgr;m in an immature vascular network produced by angiogenesis were visualized by contrast material injection into the auricular artery at a monochromatic X-ray energy of 33.2 keV just above the iodine K-edge energy. The synchrotron radiation system is a useful tool to evaluate the micro-angioarchitecture of malignant tumors in animal models of cancer for in vivo preclinical studies.

Paper Details

Date Published: 21 February 2007
PDF: 7 pages
Proc. SPIE 6501, Sensors, Cameras, and Systems for Scientific/Industrial Applications VIII, 650112 (21 February 2007); doi: 10.1117/12.702426
Show Author Affiliations
Keiji Umetani, Japan Synchrotron Radiation Research Institute (Japan)
Makito Kobatake, Kawasaki Medical School (Japan)
Akira Yamamoto, Kawasaki Medical School (Japan)
Takenori Yamashita, Kawasaki Medical School (Japan)
Shigeki Imai, Kawasaki Medical School (Japan)

Published in SPIE Proceedings Vol. 6501:
Sensors, Cameras, and Systems for Scientific/Industrial Applications VIII
Morley M. Blouke, Editor(s)

© SPIE. Terms of Use
Back to Top
Sign in to read the full article
Create a free SPIE account to get access to
premium articles and original research
Forgot your username?