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Proceedings Paper

In vivo multiphoton tomography of skin during wound healing and scar formation
Author(s): Iris Riemann; Alexander Ehlers; Ronan LeHarzic; Sven Martin; Annette Reif; Karsten König
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Paper Abstract

Multiphoton tomography based on femtosecond laser NIR (near infrared) pulses was used to perform non-invasive optical sectioning of skin with high spatial and intracellular resolution. Scar formation due to formation of collagen fibers is an important aspect during wound healing processes in skin and tissues and was monitored in vivo using the system DermaInspect. Multiphoton tomography was performed of a dermal wound after nevi extraction. The healing process and the aggregation of collagen fibers could be long term monitored due to the autofluorescence of endogenous fluorophores and SHG of collagen. The system DermaInspect might become a high resolution diagnostic tool for dermatological diagnostics and monitoring therapeutic effects.

Paper Details

Date Published: 10 February 2007
PDF: 8 pages
Proc. SPIE 6442, Multiphoton Microscopy in the Biomedical Sciences VII, 644226 (10 February 2007); doi: 10.1117/12.702407
Show Author Affiliations
Iris Riemann, Fraunhofer Institute for Biomedical Technology (Germany)
Alexander Ehlers, Fraunhofer Institute for Biomedical Technology (Germany)
Ronan LeHarzic, JenLab GmbH (Germany)
Sven Martin, JenLab GmbH (Germany)
Annette Reif, Univ. Jena (Germany)
Karsten König, Fraunhofer Institute for Biomedical Technology (Germany)

Published in SPIE Proceedings Vol. 6442:
Multiphoton Microscopy in the Biomedical Sciences VII
Ammasi Periasamy; Peter T. C. So, Editor(s)

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