
Proceedings Paper
Elicitation interval dependent spatiotemporal evolution of cortical spreading depression waves revealed by optical intrinsic signal imagingFormat | Member Price | Non-Member Price |
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Paper Abstract
This study aimed to investigate the variation of propagation patterns of successive cortical spreading depression (CSD)
waves induced by K+ or pinprick in rat cortex. In the K+ induction group, 18 Sprague-Dawley rats under
α-chloralose/urethane anesthesia were used to elicit CSD by 1 M KCl solution in the frontal cortex. Optical intrinsic
signal imaging (OISI) at an isosbestic point of hemoglobin (550 nm) was applied to examine regional cerebral blood
volume (CBV) changes in the parieto-occipital cortex. In 6 of the 18 rats, OISI was performed in conjunction with DC
potential recording of the cortex. The results of this group were reported previously. In the pinprick group, 6 rats were
used to induce CSD by pinprick with 8 min interval, and the other 6 rats were pricked with 4 min. CBV changes during
CSD appeared as repetitive propagation of wave-like hyperemia at a speed of 3.7±0.4 mm/min, which was characterized
by a significant negative peak (-14.3±3.2%) in the reflectance signal. Except for the first CSD wave, the following waves
don't spread fully in the observed cortex all the time and they might abort in the medial area. Independent on the
stimulation of pinprick or K+, a short interval of the current CSD to the last CSD no more than 4 min would induce the
current CSD be partially propagated. For the first time, the data reveals the time-varying propagation patterns of CSD
waves might be affected by the interval between CSD waves. The results suggest that the propagation patterns of a series
of CSD waves are time-varying in different regions of rat cortex, and the variation is related to the interval between CSD
waves.
Paper Details
Date Published: 15 February 2007
PDF: 11 pages
Proc. SPIE 6445, Optical Diagnostics and Sensing VII, 64450R (15 February 2007); doi: 10.1117/12.701699
Published in SPIE Proceedings Vol. 6445:
Optical Diagnostics and Sensing VII
Gerard L. Coté; Alexander V. Priezzhev, Editor(s)
PDF: 11 pages
Proc. SPIE 6445, Optical Diagnostics and Sensing VII, 64450R (15 February 2007); doi: 10.1117/12.701699
Show Author Affiliations
Shangbin Chen, Huazhong Univ. of Science and Technology (China)
Hui Gong, Huazhong Univ. of Science and Technology (China)
Shaoqun Zeng, Huazhong Univ. of Science and Technology (China)
Hui Gong, Huazhong Univ. of Science and Technology (China)
Shaoqun Zeng, Huazhong Univ. of Science and Technology (China)
Qingming Luo, Huazhong Univ. of Science and Technology (China)
Pengcheng Li, Huazhong Univ. of Science and Technology (China)
Pengcheng Li, Huazhong Univ. of Science and Technology (China)
Published in SPIE Proceedings Vol. 6445:
Optical Diagnostics and Sensing VII
Gerard L. Coté; Alexander V. Priezzhev, Editor(s)
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