
Proceedings Paper
Use of glycosylated dendrimer macromolecules to fluorescently monitor glucose concentrationFormat | Member Price | Non-Member Price |
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Paper Abstract
A minimally invasive biosensor is undergoing development to detect physiological concentrations of glucose within
interstitial fluid. The sensor is based on a chemical assay consisting of Alexa Fluor 647 labeled concanavalin A lectin
and dendrimer macromolecules functionalized to contain peripheral glucose moieties. The two components form large
cross-linked particles that result in loss of fluorescent emission through shielding of interior fluorophores. As glucose is
introduced into the assay, it competes with the glycodendrimers for binding to concanavalin A to disrupt the cross-linked
complex and produce a reversible change in fluorescence intensity that is dependent on glucose concentration.
Chemical analogs of the original glycodendrimer have been created and analyzed with the purpose of creating more
stable and consistent dendrimers in order to maximize the response of the assay so that its signal can be better detected
through dermal tissue and provide a better understanding of the sensor binding mechanics.
Paper Details
Date Published: 14 February 2007
PDF: 6 pages
Proc. SPIE 6445, Optical Diagnostics and Sensing VII, 644504 (14 February 2007); doi: 10.1117/12.701347
Published in SPIE Proceedings Vol. 6445:
Optical Diagnostics and Sensing VII
Gerard L. Coté; Alexander V. Priezzhev, Editor(s)
PDF: 6 pages
Proc. SPIE 6445, Optical Diagnostics and Sensing VII, 644504 (14 February 2007); doi: 10.1117/12.701347
Show Author Affiliations
Michael V. Pishko, The Pennsylvania State Univ. (United States)
Gerard L. Coté, Texas A&M Univ. (United States)
Gerard L. Coté, Texas A&M Univ. (United States)
Published in SPIE Proceedings Vol. 6445:
Optical Diagnostics and Sensing VII
Gerard L. Coté; Alexander V. Priezzhev, Editor(s)
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