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Proceedings Paper

Investigation and visualization of scleral channels created with femtosecond laser in enucleated human eyes using 3D optical coherence tomography images
Author(s): Gautam Chaudhary; Bin Rao; Dongyul Chai; Zhongping Chen; Tibor Juhasz
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Paper Abstract

We used optical coherence tomography (OCT) for non-invasive imaging of the anterior segment of the eye for investigating partial-thickness scleral channels created with a femtosecond laser. Glaucoma is associated with elevated intraocular pressure (IOP) due to reduced outflow facility in the eye. A partial-thickness aqueous humor (AH) drainage channel in the sclera was created with 1.7-&mgr;m wavelength femtosecond laser pulses to reduce IOP by increasing the outflow facility, as a solution to retard the progression of glaucoma. It is hypothesized that the precise dimensions and predetermined location of the channel would provide a controlled increase of the outflow rate resulting in IOP reduction. Therefore, it is significant to create the channel at the exact location with predefined dimensions. The aim of this research has two aspects. First, as the drainage channel is subsurface, it is a challenging task to determine its precise location, shape and dimensions, and it becomes very important to investigate the channel attributes after the laser treatment without disturbing the internal anterior structures. Second, to provide a non-invasive, image-based verification that extremely accurate and non-scarring AH drainage channel can be created with femtosecond laser. Partial-thickness scleral channels created in five human cadaver eyes were investigated non-invasively with a 1310-nm time-domain OCT imaging system. Three-dimensional (3D) OCT image stacks of the triangular cornea-sclera junction, also known as anterior chamber angle, were acquired for image-based analysis and visualization. The volumetric cutting-plane approach allowed reconstruction of images at any cross-sectional position in the entire 3D volume of tissue, making it a valuable tool for exploring and evaluating the location, shape and dimension of the channel from all directions. As a two-dimensional image-based methodology, an image-processing pipeline was implemented to enhance the channel features to augment the analysis. In conclusion, we successfully demonstrate that our image-based visualization tool is appropriate for effective investigation and evaluation of femtosecond laser-created, partial-thickness aqueous humor drainage channels in the sclera.

Paper Details

Date Published: 26 March 2007
PDF: 9 pages
Proc. SPIE 6426, Ophthalmic Technologies XVII, 64260B (26 March 2007); doi: 10.1117/12.701297
Show Author Affiliations
Gautam Chaudhary, Univ. of California/Irvine (United States)
Bin Rao, Univ. of California/Irvine (United States)
Beckman Laser Institute (United States)
Dongyul Chai, Univ. of California/Irvine (United States)
Zhongping Chen, Univ. of California/Irvine (United States)
Beckman Laser Institute (United States)
Tibor Juhasz, Univ. of California/Irvine (United States)

Published in SPIE Proceedings Vol. 6426:
Ophthalmic Technologies XVII
Bruce E. Stuck; Fabrice Manns; Per G. Söderberg; Michael Belkin M.D.; Arthur Ho, Editor(s)

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