
Proceedings Paper
Feasibility of multi-spectral imaging system to provide enhanced demarcation for skin tumor resectionFormat | Member Price | Non-Member Price |
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Paper Abstract
Invading tumors like basal cell carcinoma have usually no distinct demarcation for the human eye. Therefore, during
resection, an additional rim around the tumor is removed. However, extending sprouts can be missed since most lesions
are not uniform. To improve the visualization of the tumor demarcation, we developed a multi-spectral imaging system
especially adapted for dermatological applications based on tunable liquid crystal spectral tunable filter technology and
LED illumination.
Enhanced visualization of skin tumor demarcation was achieved using three strategies. The first strategy is based
on creating false color images by combining narrow band spectral filtered images by placing them into the red, green
and blue image components of a color image at three specific wavelengths. These specific wavelengths were determined
using a trial on error tool to achieve the highest contrast between malignant and healthy tissue. The second strategy is to
make ratio images of narrow band spectral filtered images at specific wavelengths. A trail on error tool was created
which enables the user to try multiple wavelengths to obtain optimal contrast. This method could be applied in realtime.
For the third strategy, on pixel spectral segmentation is applied by selecting the pixel spectra in the center of a
tumor, surrounding tissue and healthy tissue far away from the tumor. The correlation between these specific spectra
and all image pixels is calculated using a fast algorithm. The degree is correlation is graded by color coding and
presented in a false color images showing a detailed demarcation of suspicious regions in the tissue. Although this
strategy is expected to provide a higher specificity, it takes more time to calculate than the first strategy.
Paper Details
Date Published: 23 March 2007
PDF: 8 pages
Proc. SPIE 6424, Photonic Therapeutics and Diagnostics III, 64240B (23 March 2007); doi: 10.1117/12.701267
Published in SPIE Proceedings Vol. 6424:
Photonic Therapeutics and Diagnostics III
Henry Hirschberg M.D.; Brian Jet-Fei Wong M.D.; Reza S. Malek M.D.; Kenton W. Gregory M.D.; Nikiforos Kollias M.D.; Bernard Choi; Steen J. Madsen; Guillermo J. Tearney M.D.; Justus F. R. Ilgner M.D.; Haishan Zeng, Editor(s)
PDF: 8 pages
Proc. SPIE 6424, Photonic Therapeutics and Diagnostics III, 64240B (23 March 2007); doi: 10.1117/12.701267
Show Author Affiliations
Rowland de Roode, Univ. Medical Ctr. Utrecht (Netherlands)
Herke Jan Noordmans, Univ. Medical Ctr. Utrecht (Netherlands)
Herke Jan Noordmans, Univ. Medical Ctr. Utrecht (Netherlands)
Rudolf Verdaasdonk, Univ. Medical Ctr. Utrecht (Netherlands)
Published in SPIE Proceedings Vol. 6424:
Photonic Therapeutics and Diagnostics III
Henry Hirschberg M.D.; Brian Jet-Fei Wong M.D.; Reza S. Malek M.D.; Kenton W. Gregory M.D.; Nikiforos Kollias M.D.; Bernard Choi; Steen J. Madsen; Guillermo J. Tearney M.D.; Justus F. R. Ilgner M.D.; Haishan Zeng, Editor(s)
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