
Proceedings Paper
Computational aspects of endoscopic (trans-rectal) near-infrared optical tomography: initial investigationsFormat | Member Price | Non-Member Price |
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Paper Abstract
Endoscopic near-infrared (NIR) optical tomography is a novel approach that allows the blood-based high intrinsic
optical contrast to be imaged for the detection of cancer in internal organs. In endoscopic NIR tomography, the imaging
array is arranged within the interior of the medium as opposed to the exterior as seen in conventional NIR tomography
approaches. The source illuminates outward from the circular NIR probe, and the detector collects the diffused light
from the medium surrounding the NIR probe. This new imaging geometry may involve forward and inverse approaches
that are significantly different from those used in conventional NIR tomography. The implementation of a hollow-centered
forward mesh within the context of conventional NIR tomography reconstruction has already led to the first
demonstration of endoscopic NIR optical tomography. This paper presents some fundamental computational aspects
regarding the performance and sensitivity of this endoscopic NIR tomography configuration. The NIRFAST modeling
and image reconstruction package developed for conventional circular NIR geometry is used for endoscopic NIR
tomography, and initial quantitative analysis has been conducted to investigate the "effective" imaging depth, required
mesh resolution, and limit in contrast resolution, among other parameters. This study will define the performance
expected and may provide insights into hardware requirements needed for revision of NIRFAST for the endoscopic NIR
tomography geometry.
Paper Details
Date Published: 13 February 2007
PDF: 10 pages
Proc. SPIE 6434, Optical Tomography and Spectroscopy of Tissue VII, 643409 (13 February 2007); doi: 10.1117/12.700507
Published in SPIE Proceedings Vol. 6434:
Optical Tomography and Spectroscopy of Tissue VII
Britton Chance; Robert R. Alfano; Bruce J. Tromberg; Mamoru Tamura; Eva Marie Sevick-Muraca, Editor(s)
PDF: 10 pages
Proc. SPIE 6434, Optical Tomography and Spectroscopy of Tissue VII, 643409 (13 February 2007); doi: 10.1117/12.700507
Show Author Affiliations
Cameron Musgrove, Oklahoma State Univ. (United States)
Charles F. Bunting, Oklahoma State Univ. (United States)
Hamid Dehghani, Univ. of Exeter (United Kingdom)
Charles F. Bunting, Oklahoma State Univ. (United States)
Hamid Dehghani, Univ. of Exeter (United Kingdom)
Published in SPIE Proceedings Vol. 6434:
Optical Tomography and Spectroscopy of Tissue VII
Britton Chance; Robert R. Alfano; Bruce J. Tromberg; Mamoru Tamura; Eva Marie Sevick-Muraca, Editor(s)
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