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Proceedings Paper

Application of surface-enhanced Raman toward the detection of cell membrane proteins
Author(s): Li-Lin Tay; Qingyan Hu; Matthew Noestheden; John P. Pezacki
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Paper Abstract

Silver nanoparticles (Ag-NPs) functionalized with molecule probes which contains unique Raman vibrational mode as well as a recognition binding site to target specific surface proteins expressed on the transfected human cervical cancel cells was utilized to detect the cell surface protein through surface enhanced Raman scattering (SERS) microscopy. In this study, we demonstrate that only the aggregated Ag-NPs displays detectable SERS signal. We also observed striking polarization anisotropy in many dimer or trimer NP aggregates. This work will impact on the future design of NP clusters for in-vivo cell imaging.

Paper Details

Date Published: 14 February 2007
PDF: 6 pages
Proc. SPIE 6450, Plasmonics in Biology and Medicine IV, 645003 (14 February 2007); doi: 10.1117/12.700402
Show Author Affiliations
Li-Lin Tay, National Research Council Canada (Canada)
Qingyan Hu, National Research Council Canada (Canada)
Matthew Noestheden, National Research Council Canada (Canada)
John P. Pezacki, National Research Council Canada (Canada)

Published in SPIE Proceedings Vol. 6450:
Plasmonics in Biology and Medicine IV
Tuan Vo-Dinh; Joseph R. Lakowicz, Editor(s)

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