
Proceedings Paper
Monte Carlo modeling and phantom study for implantable fluorescent analyte sensors for human headFormat | Member Price | Non-Member Price |
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Paper Abstract
The overall goal for this project is the development and study of a quantitative fluorescence sensor for in vivo detection
of β-amyloid (Aβ), the primary protein component of senile plaques in Alzheimer's disease (AD). Toward achieving
that goal a Monte Carlo simulation has been developed to model photon propagation through the human head and a
phantom model of the human head has been built and tested. In both cases a four layer model that included the skin,
skull, fluorescent biosensor, and gray matter was used. A sensitivity study was performed to investigate the influence on
the fluorescent output intensity of changes in concentration of the sensor. The results show that the fluorescent output
intensity is detectable with a reasonable fluorescent sensor concentration and increases nearly linearly with increases in
fluorescent concentration in the sensor. These results imply that the sensor would be detectable through the head using a
reasonable optical system. The overall results are being used to aid in the design of the fluorescent sensor and the
optical system for early detection of AD.
Paper Details
Date Published: 15 February 2007
PDF: 7 pages
Proc. SPIE 6445, Optical Diagnostics and Sensing VII, 64450J (15 February 2007); doi: 10.1117/12.698654
Published in SPIE Proceedings Vol. 6445:
Optical Diagnostics and Sensing VII
Gerard L. Coté; Alexander V. Priezzhev, Editor(s)
PDF: 7 pages
Proc. SPIE 6445, Optical Diagnostics and Sensing VII, 64450J (15 February 2007); doi: 10.1117/12.698654
Show Author Affiliations
Qiujie Wan, Texas A&M Univ. (United States)
Hope T. Beier, Texas A&M Univ. (United States)
Bennett L. Ibey, Texas A&M Univ. (United States)
Hope T. Beier, Texas A&M Univ. (United States)
Bennett L. Ibey, Texas A&M Univ. (United States)
Theresa Good, Univ. of Maryland, Baltimore County (United States)
Gerard L. Coté, Texas A&M Univ. (United States)
Gerard L. Coté, Texas A&M Univ. (United States)
Published in SPIE Proceedings Vol. 6445:
Optical Diagnostics and Sensing VII
Gerard L. Coté; Alexander V. Priezzhev, Editor(s)
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