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Proceedings Paper

Low-coherence enhanced backscattering of light: characteristics and applications for colon cancer screening
Author(s): Young L. Kim; Prabhakar Pradhan; Vladimir M. Turzhitsky; Hariharan Subramanian; Yang Liu; Ramesh K. Wali; Hemant K. Roy; Vadim Backman
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Paper Abstract

The phenomenon of enhanced backscattering (EBS) of light, also known as coherent backscattering (CBS) of light, is a spectacular manifestation of self-interference effects in elastic light scattering, which gives rise to an enhanced scattered intensity in the backward direction. Although EBS has been the object of intensive investigation in non-biological media over the last two decades, there have been only a few attempts to explore EBS for tissue characterization and diagnosis. We have recently made progress in the EBS measurements of biological tissue by taking advantage of lowcoherence (or partially coherent) illumination, which is referred to as low-coherence EBS (LEBS) of light. LEBS possess novel and intriguing properties such as speckle reduction, self-averaging effect, broadening of the EBS width, depth-selectivity, double scattering, and circular polarization memory effect. After we review the current state of research on LEBS, we discuss how these characteristics apply for early cancer detection, especially in colorectal cancer (CRC), which is the second leading cause of cancer mortality in the United States. Although colonoscopy remains the gold standard for CRC screening, resource constraints and potential complications make it impractical to perform colonoscopy on the entire population at risk (age > 50). Thus, identifying patients who are most likely to benefit from colonoscopy is of paramount importance. We demonstrate that LEBS measurements in easily accessible colonoscopically normal mucosa (e.g., in the rectum of the colon) can be used for predicting the risk of CRC, and thus LEBS has the potential to serve as accurate markers of the risk of neoplasia elsewhere in the colon.

Paper Details

Date Published: 15 February 2007
PDF: 12 pages
Proc. SPIE 6446, Biomedical Applications of Light Scattering, 644606 (15 February 2007); doi: 10.1117/12.698622
Show Author Affiliations
Young L. Kim, Northwestern Univ. (United States)
Prabhakar Pradhan, Northwestern Univ. (United States)
Vladimir M. Turzhitsky, Northwestern Univ. (United States)
Hariharan Subramanian, Northwestern Univ. (United States)
Yang Liu, Northwestern Univ. (United States)
Ramesh K. Wali, Evanston-Northwestern Healthcare (United States)
Hemant K. Roy, Evanston-Northwestern Healthcare (United States)
Vadim Backman, Northwestern Univ. (United States)

Published in SPIE Proceedings Vol. 6446:
Biomedical Applications of Light Scattering
Adam Wax; Vadim Backman, Editor(s)

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