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Proceedings Paper

Advances in the understanding of host response associated with tumor PDT
Author(s): Mladen Korbelik
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Paper Abstract

Photodynamic therapy (PDT) is clinically established modality used for treatment of solid cancers and other conditions, which destroys lesions by localized generation of cytotoxic oxygen species mediated by administered drugs (photosensitizers) that are activated at targeted sites by exposure to light. Since over 20 years ago it has become increasingly clear that important contribution to the antitumor effect of PDT is secured by host reaction induced by this therapy and manifested as inflammatory and immune response. Presented is an overview of advances in the understanding of this host response associated with tumor PDT by tracing its evolution from initial breakthroughs and discoveries in the early 1980s, followed by advances preceding recent developments, and concluding with recently acquired knowledge and directions for clinical exploitation. Tribute is given to researchers making important contributions to this field during the last three decades including Drs. Gianfranco Canti, Julia Levy, and Barbara Henderson.

Paper Details

Date Published: 13 February 2007
PDF: 10 pages
Proc. SPIE 6438, Biophotonics and Immune Responses II, 643802 (13 February 2007); doi: 10.1117/12.698404
Show Author Affiliations
Mladen Korbelik, British Columbia Cancer Research Ctr. (Canada)

Published in SPIE Proceedings Vol. 6438:
Biophotonics and Immune Responses II
Wei R. Chen, Editor(s)

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