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Proceedings Paper

Craniofacial statistical deformation models of wild-type mice and Crouzon mice
Author(s): Hildur Ólafsdóttir; Tron A. Darvann; Bjarne K. Ersbøll; Nuno V. Hermann; Estanislao Oubel; Rasmus Larsen; Alejandro F. Frangi; Per Larsen; Chad A. Perlyn; Gillian M. Morriss-Kay; Sven Kreiborg
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Paper Abstract

Crouzon syndrome is characterised by premature fusion of cranial sutures and synchondroses leading to craniofacial growth disturbances. The gene causing the syndrome was discovered approximately a decade ago and recently the first mouse model of the syndrome was generated. In this study, a set of Micro CT scans of the heads of wild-type (normal) mice and Crouzon mice were investigated. Statistical deformation models were built to assess the anatomical differences between the groups, as well as the within-group anatomical variation. Following the approach by Rueckert et al. we built an atlas using B-spline-based nonrigid registration and subsequently, the atlas was nonrigidly registered to the cases being modelled. The parameters of these registrations were then used as input to a PCA. Using different sets of registration parameters, different models were constructed to describe (i) the difference between the two groups in anatomical variation and (ii) the within-group variation. These models confirmed many known traits in the wild-type and Crouzon mouse craniofacial anatomy. However, they also showed some new traits.

Paper Details

Date Published: 26 March 2007
PDF: 11 pages
Proc. SPIE 6512, Medical Imaging 2007: Image Processing, 65121C (26 March 2007); doi: 10.1117/12.697406
Show Author Affiliations
Hildur Ólafsdóttir, Technical Univ. of Denmark (Denmark)
Univ. of Copenhagen, Copenhagen Univ. Hospital (Denmark)
Tron A. Darvann, Univ. of Copenhagen, Copenhagen Univ. Hospital (Denmark)
Bjarne K. Ersbøll, Technical Univ. of Denmark (Denmark)
Nuno V. Hermann, Univ. of Copenhagen, Copenhagen Univ. Hospital (Denmark)
Univ. of Copenhagen (Denmark)
Estanislao Oubel, Pompeu Fabra Univ. (Spain)
Rasmus Larsen, Technical Univ. of Denmark (Denmark)
Alejandro F. Frangi, Pompeu Fabra Univ. (Spain)
Per Larsen, Univ. of Copenhagen, Copenhagen Univ. Hospital (Denmark)
Chad A. Perlyn, Washington Univ. School of Medicine (United States)
Gillian M. Morriss-Kay, Oxford Univ. (United Kingdom)
Sven Kreiborg, Univ. of Copenhagen, Copenhagen Univ. Hospital (Denmark)
Univ. of Copenhagen (Denmark)

Published in SPIE Proceedings Vol. 6512:
Medical Imaging 2007: Image Processing
Josien P. W. Pluim; Joseph M. Reinhardt, Editor(s)

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