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Proceedings Paper

Muller matrix approach for determination of optical rotation in chiral turbid media in backscattering geometry
Author(s): S. Manhas; M. K. Swami; P. Buddhiwant; N. Ghosh; P. K. Gupta; K. Singh
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Paper Abstract

For in vivo determination of optically active (chiral) substances in turbid media, like for example glucose in human tissue, the backscattering geometry is particularly convenient. However, recent polarimetric measurements performed in the backscattering geometry have shown that, in this geometry, the relatively small rotation of the polarization vector arising due to the optical activity of the medium is totally swamped by the much larger changes in the orientation angle of the polarization vector due to scattering. We show that the change in the orientation angle of the polarization vector arises due to the combined effect of linear diattenuation and linear retardance of light scattered at large angles and can be decoupled from the pure optical rotation component using polar decomposition of Mueller matrix. For this purpose, the method developed earlier for polar decomposition of Mueller matrix was extended to incorporate optical rotation in the medium. The validity of this approach for accurate determination of the degree of optical rotation using the Mueller matrix measured from the medium in both forward and backscattering geometry was tested by conducting studies on chiral turbid samples prepared using known concentration of scatterers and glucose molecules.

Paper Details

Date Published: 21 July 2006
PDF: 11 pages
Proc. SPIE 6163, Saratov Fall Meeting 2005: Optical Technologies in Biophysics and Medicine VII, 61630W (21 July 2006); doi: 10.1117/12.697294
Show Author Affiliations
S. Manhas, Ctr. for Advanced Technology (India)
M. K. Swami, Indian Institute of Technology, Delhi (India)
P. Buddhiwant, Ctr. for Advanced Technology (India)
N. Ghosh, Ctr. for Advanced Technology (India)
P. K. Gupta, Ctr. for Advanced Technology (India)
K. Singh, Indian Institute of Technology, Delhi (India)

Published in SPIE Proceedings Vol. 6163:
Saratov Fall Meeting 2005: Optical Technologies in Biophysics and Medicine VII
Valery V. Tuchin, Editor(s)

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