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Proceedings Paper

Molecular breast imaging using a dedicated, high-performance instrument
Author(s): Michael K. O'Connor; Douglas Wagenaar; Carrie B. Hruska; Stephen Phillips; Gina Caravaglia; Deborah Rhodes
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Paper Abstract

In women with radiographically dense breasts, the sensitivity of mammography is less than 50%. With the increase in the percent of women with dense breasts, it is important to look at alternative screening techniques for this population. This article reviews the strengths and weaknesses of current imaging techniques and focuses on recent developments in semiconductor-based gamma camera systems that offer significant improvements in image quality over that achievable with single-crystal sodium iodide systems. We have developed a technique known as Molecular Breast Imaging (MBI) using small field of view Cadmium Zinc Telluride (CZT) gamma cameras that permits the breast to be imaged in a similar manner to mammography, using light pain-free compression. Computer simulations and experimental studies have shown that use of low-energy high sensitivity collimation coupled with the excellent energy resolution and intrinsic spatial resolution of CZT detectors provides optimum image quality for the detection of small breast lesions. Preliminary clinical studies with a prototype dual-detector system have demonstrated that Molecular Breast Imaging has a sensitivity of ~90% for the detection of breast tumors less than 10 mm in diameter. By comparison, conventional scintimammography only achieves a sensitivity of 50% in the detection of lesions < 10 mm. Because Molecular Breast Imaging is not affected by breast density, this technique may offer an important adjunct to mammography in the evaluation of women with dense breast parenchyma.

Paper Details

Date Published: 22 September 2006
PDF: 15 pages
Proc. SPIE 6319, Hard X-Ray and Gamma-Ray Detector Physics and Penetrating Radiation Systems VIII, 63191D (22 September 2006); doi: 10.1117/12.687621
Show Author Affiliations
Michael K. O'Connor, Mayo Clinic (United States)
Douglas Wagenaar, Gamma Medica-Ideas, Inc. (United States)
Carrie B. Hruska, Mayo Clinic (United States)
Stephen Phillips, Mayo Clinic (United States)
Gina Caravaglia, Gamma Medica-Ideas, Inc. (United States)
Deborah Rhodes, Mayo Clinic (United States)

Published in SPIE Proceedings Vol. 6319:
Hard X-Ray and Gamma-Ray Detector Physics and Penetrating Radiation Systems VIII
F. Patrick Doty; Larry A. Franks; Arnold Burger; H. Bradford Barber; Hans Roehrig; Ralph B. James, Editor(s)

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