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Proceedings Paper

Breath acetone detection
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Paper Abstract

Acetone is a good marker of metabolic stress as it is the most volatile and rapidly equilibrated of the ketone bodies produced by human metabolism. If the body utilizes predominately fat to meet its energy requirements, blood and breath acetone concentrations will increase. Elevated concentrations of breath acetone can indicate a normal response to caloric imbalances in the diet, or a diseased state such as untreated diabetes. This paper describes a novel method of acetone detection that uses a gas-solid chemical reaction of acetone with a hydroxylamine hydrochloride (HA) to produce an easily detectable chemical species, HCl. Breath samples are passed through a reactor filled with solid HA and the amount of HCl gas released is measured by sensitive near infrared diode laser spectroscopy. The breath acetone instrument described is compact, low power and portable.

Paper Details

Date Published: 17 October 2006
PDF: 8 pages
Proc. SPIE 6386, Optical Methods in the Life Sciences, 63860O (17 October 2006); doi: 10.1117/12.685276
Show Author Affiliations
Steve M. Massick, Southwest Sciences, Inc. (United States)
Andrei Vakhtin, Southwest Sciences, Inc. (United States)

Published in SPIE Proceedings Vol. 6386:
Optical Methods in the Life Sciences
Alexey A. Belyanin; Mostafa Analoui; Rebekah Anna Drezek; Claire F. Gmachl, Editor(s)

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