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Proceedings Paper

A fractal analysis of pathogen detection by biosensors
Author(s): Atul M. Doke; Ajit Sadana
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Paper Abstract

A fractal analysis is presented for the detection of pathogens such as Franscisela tularensis, and Yersinia pestis (the bacterium that causes plague) using a CANARY (cellular analysis and notification of antigens risks and yields) biosensor (Rider et al., 2003). In general, the binding and dissociation rate coefficients may be adequately described by either a single- or a dual-fractal analysis. An attempt is made to relate the binding rate coefficient to the degree of heterogeneity (fractal dimension value) present on the biosensor surface. Binding and dissociation rate coefficient values obtained are presented. The kinetics aspects along with the affinity values presented are of interest, and should along with the rate coefficients presented for the binding and the dissociation phase be of significant interest in help designing better biosensors for an application area that is bound to gain increasing importance in the future.

Paper Details

Date Published: 19 May 2006
PDF: 10 pages
Proc. SPIE 6218, Chemical and Biological Sensing VII, 62180Q (19 May 2006); doi: 10.1117/12.664721
Show Author Affiliations
Atul M. Doke, Univ. of Mississippi (United States)
Ajit Sadana, Univ. of Mississippi (United States)

Published in SPIE Proceedings Vol. 6218:
Chemical and Biological Sensing VII
Patrick J. Gardner; Augustus W. Fountain III, Editor(s)

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